In a similar way, I would say, in the cardiac myosin inhibitors, it is difficult and not appropriate probably for us to comment on other people's drug as to what a profile is going to look like and if they will have any warning and precautions in the label or not. What we can say though is again I believe in Camzyos as already alluded to buy by Chris well and David his remarks are our believe in the data and our physicians are acting in terms of getting trained and prescribing it to the patients. So overall, looking forward to the initiation of our non-obstructive Hypertrophic Cardiomyopathy Phase 3 program towards the end of the year. Thank you.$细胞动力科技(CYTK)$ $百时美施贵宝(BMY)$