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仔细看看这个临床设计,入选标准是和阳性患者接触96小时内的家庭成员,可问题是,从北京流调看,96小时足够传播一代了,还得考虑这个阳性患者是感染后多长时间内检测出来的。
话说辉瑞是不是临床设计时,小看了Omicron的传播能力?相当一部分人,怕是还没入组就已经被感染了[大笑]
$君实生物-U(SH688180)$

About the Phase 2/3 EPIC-PEP Study
The top-line analysis evaluated data from 2,957 adults. Enrolled adults had a negative SARS-CoV-2 rapid antigen test result and were asymptomatic household contacts with exposure within 96 hours to an individual who was symptomatic and recently tested positive for SARS-CoV-2. Each patient was randomized (1:1:1) to receive orally twice daily one of the following: (i) PAXLOVID for five days followed by placebo for 5 days, (ii) PAXLOVID for ten days or (iii) placebo for ten days.
引用:
2022-04-30 09:06
辉瑞Paxlovid新冠预防临床试验顶线数据发布,有效但是没有达到统计学终点。
必须得说,人家给自己设置的门槛还是很高的,结果出来立刻公布,有效就是有效,没达到终点就是没达到终点,比某些国产药靠谱。预防不是张口就来的,不过也好,辉瑞开路,国产药跟上避免踩坑。
NEW YORK, April 29...