$索伦托医疗(SRNE)$ 今日一新闻另到索伦托大幅收涨。说说我的理解 1 mayo 诊所将自己研发几年的adnab给药平台授权给索伦托进行继续的发展和后续的商业化。mayo 诊所是医学界的权威，无论是科研还是临床水平都是。足以体现出索伦托在这免疫疗法方面的优势。 2 目前abnab给药平台已经成功给复发性或难治性的弥漫性大细胞性b淋巴瘤的病人和9个子宫内膜癌的病人。虽然还没有数据，但是负责项目和跟踪的医生都觉得项目潜力非常大。 3 Henry ji 说 以后还会将adnab这个给药平台应用到其他疾病，例如实体瘤，和自身免疫疾病。这个给药平台是白蛋白与纳米药结合成的可以的靶向单克隆抗体，所以对其他药物的延展性。应该是很高的。
以下是这则新闻的具体内容。 Sorrento Announces Subsidiary Company - ADNAB, Inc. - to Develop and Commercialize ADNAB™ Platform Products for Hematological Malignancies and Solid Tumors Based on an Exclusive Technology License From the Mayo Clinic
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The ADNAB™ platform was developed and exclusively licensed to Sorrento by the Mayo Clinic
Clinical studies utilizing the ADNAB™ platform are ongoing at the Mayo Clinic; and are evaluating multiple platform-generated products in advanced-stage: endometrial cancer, ovarian cancer, angiosarcoma, and B-Cell lymphomas
Study LS1681 is a Mayo Investigator-Initiated-Trial (IIT) for relapsed or refractory B-cell lymphomas; and is evaluating rituximab-ADNAB™ (nab-paclitaxel nanoparticles non-covalently coated with rituximab)1
Study MC1371 is a Mayo Investigator-Initiated-Trial (IIT) for various solid tumors; and has completed a dose escalation phase2. To date, 9 endometrial and ovarian cancer patients, that had failed at least one prior regimen containing bevacizumab, were treated with bevacizumab-ADNAB™ (nab-paclitaxel nanoparticles non-covalently coated with bevacizumab).3
An ADNAB™ is an immune complex of nanoparticle albumin-bound drug products e.g., nab-paclitaxel, which are non-covalently conjugated with tumor-targeting monoclonal antibodies (mAb’s). The ADNAB™ platform was developed by Svetomir Markovic, M.D., Ph.D., and his research team at Mayo Clinic. To date, Dr. Markovic’s team have successfully formed nine (9) potential ADNAB™ candidates, including two (2) that are currently enrolling in an FDA supervised, investigator-initiated human trial.
Utilizing Sorrento’s G-MAB™ library of fully humanized monoclonal antibodies, the ADNAB™ platform will generate a broad portfolio of product candidates targeting liquid and solid tumors. “We believe this platform has broad potential.” said Henry Ji, Ph.D., Chairman and CEO of the newly formed ADNAB, Inc. “Our Vision, is to extend the reach of this platform to therapeutic areas beyond oncology; we have already begun work on an ADNAB™ for auto-immune diseases.”
Mayo Clinic physician Tom Habermann, M.D., serves as the Principal Investigator for Study LS1681, which is evaluating a rituximab-ADNAB™ in relapsed/refractory B-cell lymphomas. Relapsed-Refractory Diffuse Large B Cell Lymphoma (RR DLBCL), which accounts for approximately one-third of patients with DLBCL, remains a major cause of morbidity and mortality.
“I think this technology has the potential to be impactful” said Bradley J. Monk, M.D., Professor of Gynecologic Oncology at the University of Arizona College of Medicine. “I’m especially excited by the flexibility of this platform and I’m anxious to see what we might be able to do with a product that targets CA-125,” added Dr. Monk.
“The Mayo team has spent years fine-tuning this technology and now we have a collaborator that can provide the resources necessary to accelerate and scale this program,” said Svetomir Markovic, M.D., Ph.D., who discovered and developed the ADNAB™ platform technology.
“The published clinical studies testing this platform technology are encouraging and we are looking forward to working with the Mayo team on both the ongoing and future clinical studies. Unquestionably, Sorrento and Mayo share the common goal of utilizing this technology to develop multiple therapies for the possible benefit of cancer patients,” noted Ji.
ADNAB, Inc. plans to file multiple INDs this year; and to request Breakthrough Therapy designation from the FDA in both ovarian and endometrial cancers.