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这5家岂不是海外巨头认证的毫无研发能力的药企
亡我之心不死！这种敌对国的企业授权的药能用？绝对有毒！我要吃中药
感谢默沙东。
我不认为这个药应该广泛使用，我甚至认为能不用就不用。我奉劝游资不要见得风就是雨，疯狂炒作。具体原因包括它可能令病毒更快突变，也可能整合到人的细胞的DNA中而造成人的细胞的突变，造成胚胎畸形（它可以诱导大鼠胚胎突变）等风险。请参考这篇文章，我把重点摘录在后面：网页链接
Top-line results from molnupiravir in 1,433 patients show the drug reduced hospitalization or death by 30% when it was administered within 5 days of symptom onset. Rosier interim results, showing a 48% reduction, analysed fewer people; molnupiravir didn’t have an edge in the second half of the trial.
In the FDA’s advisory committee meeting on the drug, experts voted narrowly in favour of authorization. But 10 panellists felt that the drug’s benefits did not justify its risks.
Because molnupiravir induces errors in viral RNA, one key concern is that it could theoretically speed up the evolution of this viral foe. This risk is greatest in immunocompromised patients, who may incubate and shed virus for longer, and in patients who take lower doses or shorter drug courses than prescribed. Merck’s counterargument — that the virus was undetectable at the end of treatment in the clinic, suggesting that mutant viruses that arise are quickly cleared — did not convince all the committee members.
Another issue is that molnupiravir might be incorporated into human DNA, causing mutations in rapidly dividing human tissues including fetuses. These mutagenic concerns are not new: Pharmasset reportedly abandoned development of structurally related compounds in 2003 due to their mutagenic potential.
Molnupiravir causes mutations in the Ames test, which assesses mutagenic potential in bacterial cells. One follow-up study in mice produced inconclusive results, and another showed that the drug was not mutagenic in whole animals, Merck showed. Some committee members questioned Merck’s models and controls.
Molnupiravir also induced fetal mutations in rats. “The FDA should not approve it for pregnant women except in exceptional circumstances,” summarized David Eastmond, a toxicologist at the University of California and an FDA advisory committee member.
默沙东伟大的公司，当初乙肝疫苗也是他捐给中国的。
默克这个从临床效果看比辉瑞的差得远
这招真高，让你永远无动力自己去创新。
据Harvard T.H. Chan 公卫学院公布的Molnupiravir 处方信息，该药每盒 40 粒胶囊，售价 712 美元（估计生产成本 17.74 美元），需每日服用两次，每次 4 粒，连服 5 天。