And then on CARVYKTI, we're really pleased with how the product is performing for patients and the data that we're continuing to see, maybe if I start off on CARTITUDE-4 and then I'll come back on the launch. We do anticipate CARTITUDE-4 hopefully reporting by year-end. It's an event driven trial. So we have to wait until we have all of the events. But that’s currently what we're planning for now, so that everyone knows CARTITUDE-4 is our study that takes a look at CARVYKTI in one to three prior lines of therapy. We're really interested and looking forward to seeing those results.
So if we take a look at the early launch for CARVYKTI, we've always talked about this being really planned and thoughtful approach to scaling it. And so we're in the process right now. We've really been working closely with the centers where we had done the clinical trials to work through the initial phases. I know everyone knows about the worldwide lentivirus shortage. We've made really good progress on that and have good line of sight to that not being something that we're dependent, that not being a rate-limiting factor in the future. We're also working towards really being able to scale this at a broad level to be able to accommodate what we're seeing is both great demand for the product right now, but also what we anticipate with CARTITUDE-4, as well as hopefully with CARTITUDE-5, which would be in frontline therapy. So we reconfirm this as really a big asset with a lot of growth potential and one of our potentially $5 billion-plus brands.