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$康宁杰瑞制药-B(09966)$ In the Phase 2 MSI-H/dMMR advanced solid tumor trial, the confirmed objective response rate (ORR) by blinded independent central review in MSI-H/dMMR colorectal cancer (CRC) patients treated with envafolimab who failed a fluoropyrimidine, oxaliplatin and irinotecan was 32%, which was similar to the 28% confirmed ORR reported in the Opdivo package insert in MSI-H/dMMR CRC patients who failed a fluoropyrimidine, oxaliplatin, and irinotecan and the 33% confirmed ORR reported for Keytruda in MSI-H/dMMR CRC patients who failed a fluoropyrimidine, oxaliplatin and irinotecan in cohort A of the KEYNOTE-164 clinical trial

K药,O药作为单抗,是和KN035比较的东西。而KN046是在KN035的基础上研发的,现在还在质疑KN046的不如单抗的,再去仔细看看报告。

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2021-06-02 08:35

在2期MSI-H/dMMR晚期实体瘤试验中,使用envafolimab治疗失败的MSI-H/dMMR结直肠癌(CRC)患者,经盲法独立中心回顾证实的客观有效率(ORR)为32%,这与KEYNOTE-164临床试验a组MSI-H/dMMR CRC患者氟嘧啶、奥沙利铂和伊立替康治疗失败后Opdivo包插入报告的28%确诊ORR相似,而Keytruda治疗失败的MSI-H/dMMR CRC患者报告的33%确诊ORR相似