二期确实结果比较吊诡,这个三期从开始就疑云重重。
No significant differences as compared to placebo were achieved on the key secondary endpoints, including fibrosis improvement of at least one stage and changes in metabolic parameters (triglycerides, Non-HDL Cholesterol, HDL Cholesterol, LDL Cholesterol, HOMA-IR in non diabetic patients, and HbA1c in diabetic patients).
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一早就看到了Genfit惨案,Elafibranor三期临床未达到主要临床终点,看了一眼数字确实是有点被盖上棺材板的意思,NASH和纤维化全都扑街了,加上之前死掉的Cymabay品种,看起来PPAR机制已经是死一户口本了……
$Genfit(GNFT)$ $Intercept制药(ICPT)$ $海普瑞(SZ002399)$